Parsanathan, R. & Jain, S. K. Novel invasive and noninvasive cardiac-specific biomarkers in obesity and cardiovascular diseases. Metab. Syndr. Relat. Disord. 18(1), 10–30 (2020).
Google Scholar
Bays, H. E. et al. Ten things to know about ten cardiovascular disease risk factors – 2022. Am. J. Prev. Cardiol. 10, 100342 (2022).
Google Scholar
Keramat, S. A. et al. Obesity and the risk of developing chronic diseases in middle-aged and older adults: Findings from an Australian longitudinal population survey, 2009–2017. PLoS One 16(11), e0260158 (2021).
Google Scholar
NHLBI. Managing Overweight and Obesity in Adults: Systematic Evidence Review from the Obesity Expert Panel (2013).
Pierantonelli, I. & Svegliati-Baroni, G. Nonalcoholic fatty liver disease: basic pathogenetic mechanisms in the progression from NAFLD to NASH. Transplantation. 103(1), e1–e13 (2019).
Google Scholar
Overview of Obesity. Accessed 30 May, 2023.
Obesity. Accessed 30 May, 2023.
Wang, Y. et al. Global burden of digestive diseases: a systematic analysis of the global burden of diseases study, 1990 to 2019. Gastroenterology 165(3), 773-783.e715 (2023).
Google Scholar
Wang, F. et al. Global, regional, and national burden of digestive diseases: findings from the global burden of disease study 2019. Front. Public Health 11, 1202980 (2023).
Google Scholar
Hunt, R. H. et al. The stomach in health and disease. Gut 64(10), 1650–1668 (2015).
Google Scholar
Lezutekong, J. N., Nikhanj, A. & Oudit, G. Y. Imbalance of gut microbiome and intestinal epithelial barrier dysfunction in cardiovascular disease. Clin. Sci. 132(8), 901–904 (2018).
Koh, J. C. et al. Asian consensus on the relationship between obesity and gastrointestinal and liver diseases. J. Gastroenterol. Hepatol. 31(8), 1405–1413 (2016).
Google Scholar
Nam, S. Y. Obesity-related digestive diseases and their pathophysiology. Gut Liver 11(3), 323–334 (2017).
Google Scholar
Elsayed, E. F. et al. Waist-to-hip ratio and body mass index as risk factors for cardiovascular events in CKD. Am. J. Kidney Dis. 52(1), 49–57 (2008).
Google Scholar
Nalini, M. et al. Comparing anthropometric indicators of visceral and general adiposity as determinants of overall and cardiovascular mortality. Arch. Iran. Med. 22(6), 301–309 (2019).
Google Scholar
Jang, H. et al. Overall and abdominal obesity and risks of all-cause and cause-specific mortality in Korean adults: a pooled analysis of three population-based prospective cohorts. Int. J. Epidemiol. 52(4), 1060–1073 (2023).
Google Scholar
Fry, A. et al. Comparison of sociodemographic and health-related characteristics of UK biobank participants with those of the general population. Am. J. Epidemiol. 186(9), 1026–1034 (2017).
Google Scholar
UK Biobank: Protocol for a large-scale prospective epidemiological resource. Accessed December, 2022.
WHO Discussion Paper: Draft recommendations for the prevention and management of obesity over the life course, including potential targets. (2021).
Després, J. P. Abdominal obesity and cardiovascular disease: is inflammation the missing link?. Can. J. Cardiol. 28(6), 642–652 (2012).
Google Scholar
Hirshkowitz, M. et al. National Sleep Foundation’s sleep time duration recommendations: methodology and results summary. Sleep Health 1(1), 40–43 (2015).
Google Scholar
Townsend, P. Deprivation. J. Soc. Policy 16(2), 125–146 (1987).
Google Scholar
Craig, C. L. et al. International physical activity questionnaire: 12-country reliability and validity. Med. Sci. Sports Exerc. 35(8), 1381–1395 (2003).
Google Scholar
Wang, Y. C., McPherson, K., Marsh, T., Gortmaker, S. L. & Brown, M. Health and economic burden of the projected obesity trends in the USA and the UK. Lancet (London, England). 378(9793), 815–825 (2011).
Google Scholar
Ballou, S. et al. Obesity is associated with significantly increased risk for diarrhoea after controlling for demographic, dietary and medical factors: a cross-sectional analysis of the 2009–2010 National Health and Nutrition Examination Survey. Aliment. Pharmacol. Ther. 50(9), 1019–1024 (2019).
Google Scholar
Preston, S. H. & Stokes, A. Obesity paradox: conditioning on disease enhances biases in estimating the mortality risks of obesity. Epidemiology (Cambridge, Mass) 25(3), 454–461 (2014).
Google Scholar
Kartheuser, A. H. et al. Waist circumference and waist/hip ratio are better predictive risk factors for mortality and morbidity after colorectal surgery than body mass index and body surface area. Ann. Surg. 258(5), 722–730 (2013).
Google Scholar
Fedirko, V. et al. Pre-diagnostic anthropometry and survival after colorectal cancer diagnosis in Western European populations. Int. J. Cancer 135(8), 1949–1960 (2014).
Google Scholar
Goh, L. Y. & Goh, K. L. Obesity: an epidemiological perspective from Asia and its relationship to gastrointestinal and liver cancers. J. Gastroenterol. Hepatol. 28(Suppl 4), 54–58 (2013).
Google Scholar
Aune, D. et al. Body mass index, abdominal fatness and pancreatic cancer risk: a systematic review and non-linear dose-response meta-analysis of prospective studies. Ann. Oncol. 23(4), 843–852 (2012).
Google Scholar
Li, X. et al. Abdominal obesity and digestive system cancer: a systematic review and meta-analysis of prospective studies. BMC Public Health 23(1), 2343 (2023).
Google Scholar
Stefan, N. et al. Identification and characterization of metabolically benign obesity in humans. Arch. Intern. Med. 168(15), 1609–1616 (2008).
Google Scholar
Zou, Y. & Pitchumoni, C. S. Obesity, obesities and gastrointestinal cancers. Disease-a-Month 69(12), 101592 (2023).
Google Scholar
Genkinger, J. M., Kitahara, C. M., Bernstein, L., Berrington de Gonzalez, A., Brotzman, M., Elena, J. W. et al. Central adiposity, obesity during early adulthood, and pancreatic cancer mortality in a pooled analysis of cohort studies. Ann. Oncol. 26(11), 2257–2266 (2015).
Liu, X. et al. Overweight and obesity as independent factors for increased risk of hepatocellular cancer-related mortality: a meta-analysis. J. Am. Coll. Nutr. 40(3), 287–293 (2021).
Google Scholar
Kim, H. S. et al. Synergistic associations of PNPLA3 I148M variant, alcohol intake, and obesity with risk of cirrhosis, hepatocellular carcinoma, and mortality. JAMA Netw. Open 5(10), e2234221 (2022).
Google Scholar
Simon, T. G. et al. Physical activity compared to adiposity and risk of liver-related mortality: Results from two prospective, nationwide cohorts. J. Hepatol. 72(6), 1062–1069 (2020).
Google Scholar
Emerenziani, S., Guarino, M. P. L., Trillo Asensio, L. M., Altomare, A., Ribolsi, M., Balestrieri, P. et al. Role of overweight and obesity in gastrointestinal disease. Nutrients 12(1) (2019).
Ze, E. Y., Kim, B. J., Kang, H. & Kim, J. G. Abdominal visceral to subcutaneous adipose tissue ratio is associated with increased risk of erosive esophagitis. Dig. Dis. Sci. 62(5), 1265–1271 (2017).
Google Scholar
Lauby-Secretan, B. et al. Body fatness and cancer-viewpoint of the IARC Working Group. N. Engl. J. Med. 375(8), 794–798 (2016).
Google Scholar
Kredel, L., Batra, A. & Siegmund, B. Role of fat and adipokines in intestinal inflammation. Curr. Opin. Gastroenterol. 30(6), 559–565 (2014).
Google Scholar
Iacobini, C., Pugliese, G., Blasetti Fantauzzi, C., Federici, M. & Menini, S. Metabolically healthy versus metabolically unhealthy obesity. Metabolism 92, 51–60 (2019).
Lotta, L. A. et al. Integrative genomic analysis implicates limited peripheral adipose storage capacity in the pathogenesis of human insulin resistance. Nat. Genet. 49(1), 17–26 (2017).
Google Scholar
Stefan, N., Schick, F. & Häring, H. U. Causes, characteristics, and consequences of metabolically unhealthy normal weight in humans. Cell Metab. 26(2), 292–300 (2017).
Google Scholar
Michalsen, V. L. et al. Obesity measures, metabolic health and their association with 15-year all-cause and cardiovascular mortality in the SAMINOR 1 Survey: a population-based cohort study. BMC Cardiovasc. Disord. 21(1), 510 (2021).
Google Scholar
Neeland, I. J. et al. Visceral and ectopic fat, atherosclerosis, and cardiometabolic disease: a position statement. Lancet Diabetes Endocrinol. 7(9), 715–725 (2019).
Google Scholar
Darin-Mattsson, A., Fors, S. & Kåreholt, I. Different indicators of socioeconomic status and their relative importance as determinants of health in old age. Int. J. Equity Health 16(1), 173 (2017).
Google Scholar
Mackenbach, J. P. et al. Changes in mortality inequalities over two decades: register based study of European countries. BMJ (Clin. Res. Ed) 353, i1732 (2016).
Chetty, R. et al. The association between income and life expectancy in the United States, 2001–2014. JAMA 315(16), 1750–1766 (2016).
Google Scholar
Stringhini, S. et al. Socioeconomic status and the 25 × 25 risk factors as determinants of premature mortality: a multicohort study and meta-analysis of 1·7 million men and women. Lancet (London, England) 389(10075), 1229–1237 (2017).
Google Scholar
Kaul, S. et al. Modifiable health-related factors (smoking, physical activity and body mass index) and health care use and costs among adult cancer survivors. J. Cancer Res. Clin. Oncol. 143(12), 2469–2480 (2017).
Google Scholar
Schweda, S., Munz, B., Burgstahler, C., Niess, A. M., Roesel, I., Sudeck, G. et al. Proof of concept of a 6-month person-oriented exercise intervention ‘multipill-exercise’ among patients at risk of or with multiple chronic diseases: Results of a One-Group Pilot Trial. Int. J. Environ. Res. Public Health 19(15) (2022).
Wang, C., Zhang, X., Li, B. & Mu, D. A study of factors impacting disease based on the Charlson Comorbidity Index in UK Biobank. Front. Public Health 10, 1050129 (2022).
Google Scholar
Gardner, J. D. & Mouton, A. J. Alcohol effects on cardiac function. Compr. Physiol. 5(2), 791–802 (2015).
Google Scholar
Stockwell, T. et al. Do, “moderate” drinkers have reduced mortality risk? A systematic review and meta-analysis of alcohol consumption and all-cause mortality. J. Stud. Alcohol Drugs 77(2), 185–198 (2016).
Google Scholar
Fekjaer, H. O. Alcohol-a universal preventive agent? A critical analysis. Addiction (Abingdon, England) 108(12), 2051–2057 (2013).
Google Scholar
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