December 9, 2024

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The role of obesity in mortality from digestive diseases in UK Biobank

  • Parsanathan, R. & Jain, S. K. Novel invasive and noninvasive cardiac-specific biomarkers in obesity and cardiovascular diseases. Metab. Syndr. Relat. Disord. 18(1), 10–30 (2020).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Bays, H. E. et al. Ten things to know about ten cardiovascular disease risk factors – 2022. Am. J. Prev. Cardiol. 10, 100342 (2022).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Keramat, S. A. et al. Obesity and the risk of developing chronic diseases in middle-aged and older adults: Findings from an Australian longitudinal population survey, 2009–2017. PLoS One 16(11), e0260158 (2021).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • NHLBI. Managing Overweight and Obesity in Adults: Systematic Evidence Review from the Obesity Expert Panel (2013).

  • Pierantonelli, I. & Svegliati-Baroni, G. Nonalcoholic fatty liver disease: basic pathogenetic mechanisms in the progression from NAFLD to NASH. Transplantation. 103(1), e1–e13 (2019).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Overview of Obesity. Accessed 30 May, 2023.

  • Obesity. Accessed 30 May, 2023.

  • Wang, Y. et al. Global burden of digestive diseases: a systematic analysis of the global burden of diseases study, 1990 to 2019. Gastroenterology 165(3), 773-783.e715 (2023).

    Article 
    PubMed 

    Google Scholar 

  • Wang, F. et al. Global, regional, and national burden of digestive diseases: findings from the global burden of disease study 2019. Front. Public Health 11, 1202980 (2023).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Hunt, R. H. et al. The stomach in health and disease. Gut 64(10), 1650–1668 (2015).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Lezutekong, J. N., Nikhanj, A. & Oudit, G. Y. Imbalance of gut microbiome and intestinal epithelial barrier dysfunction in cardiovascular disease. Clin. Sci. 132(8), 901–904 (2018).

  • Koh, J. C. et al. Asian consensus on the relationship between obesity and gastrointestinal and liver diseases. J. Gastroenterol. Hepatol. 31(8), 1405–1413 (2016).

    Article 
    PubMed 

    Google Scholar 

  • Nam, S. Y. Obesity-related digestive diseases and their pathophysiology. Gut Liver 11(3), 323–334 (2017).

    Article 
    MathSciNet 
    CAS 
    PubMed 

    Google Scholar 

  • Elsayed, E. F. et al. Waist-to-hip ratio and body mass index as risk factors for cardiovascular events in CKD. Am. J. Kidney Dis. 52(1), 49–57 (2008).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Nalini, M. et al. Comparing anthropometric indicators of visceral and general adiposity as determinants of overall and cardiovascular mortality. Arch. Iran. Med. 22(6), 301–309 (2019).

    PubMed 

    Google Scholar 

  • Jang, H. et al. Overall and abdominal obesity and risks of all-cause and cause-specific mortality in Korean adults: a pooled analysis of three population-based prospective cohorts. Int. J. Epidemiol. 52(4), 1060–1073 (2023).

    Article 
    PubMed 

    Google Scholar 

  • Fry, A. et al. Comparison of sociodemographic and health-related characteristics of UK biobank participants with those of the general population. Am. J. Epidemiol. 186(9), 1026–1034 (2017).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • UK Biobank: Protocol for a large-scale prospective epidemiological resource. Accessed December, 2022.

  • WHO Discussion Paper: Draft recommendations for the prevention and management of obesity over the life course, including potential targets. (2021).

  • Després, J. P. Abdominal obesity and cardiovascular disease: is inflammation the missing link?. Can. J. Cardiol. 28(6), 642–652 (2012).

    Article 
    PubMed 

    Google Scholar 

  • Hirshkowitz, M. et al. National Sleep Foundation’s sleep time duration recommendations: methodology and results summary. Sleep Health 1(1), 40–43 (2015).

    Article 
    PubMed 

    Google Scholar 

  • Townsend, P. Deprivation. J. Soc. Policy 16(2), 125–146 (1987).

    Article 

    Google Scholar 

  • Craig, C. L. et al. International physical activity questionnaire: 12-country reliability and validity. Med. Sci. Sports Exerc. 35(8), 1381–1395 (2003).

    Article 
    PubMed 

    Google Scholar 

  • Wang, Y. C., McPherson, K., Marsh, T., Gortmaker, S. L. & Brown, M. Health and economic burden of the projected obesity trends in the USA and the UK. Lancet (London, England). 378(9793), 815–825 (2011).

    Article 
    PubMed 

    Google Scholar 

  • Ballou, S. et al. Obesity is associated with significantly increased risk for diarrhoea after controlling for demographic, dietary and medical factors: a cross-sectional analysis of the 2009–2010 National Health and Nutrition Examination Survey. Aliment. Pharmacol. Ther. 50(9), 1019–1024 (2019).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Preston, S. H. & Stokes, A. Obesity paradox: conditioning on disease enhances biases in estimating the mortality risks of obesity. Epidemiology (Cambridge, Mass) 25(3), 454–461 (2014).

    Article 
    PubMed 

    Google Scholar 

  • Kartheuser, A. H. et al. Waist circumference and waist/hip ratio are better predictive risk factors for mortality and morbidity after colorectal surgery than body mass index and body surface area. Ann. Surg. 258(5), 722–730 (2013).

    Article 
    PubMed 

    Google Scholar 

  • Fedirko, V. et al. Pre-diagnostic anthropometry and survival after colorectal cancer diagnosis in Western European populations. Int. J. Cancer 135(8), 1949–1960 (2014).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Goh, L. Y. & Goh, K. L. Obesity: an epidemiological perspective from Asia and its relationship to gastrointestinal and liver cancers. J. Gastroenterol. Hepatol. 28(Suppl 4), 54–58 (2013).

    Article 
    PubMed 

    Google Scholar 

  • Aune, D. et al. Body mass index, abdominal fatness and pancreatic cancer risk: a systematic review and non-linear dose-response meta-analysis of prospective studies. Ann. Oncol. 23(4), 843–852 (2012).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Li, X. et al. Abdominal obesity and digestive system cancer: a systematic review and meta-analysis of prospective studies. BMC Public Health 23(1), 2343 (2023).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Stefan, N. et al. Identification and characterization of metabolically benign obesity in humans. Arch. Intern. Med. 168(15), 1609–1616 (2008).

    Article 
    PubMed 

    Google Scholar 

  • Zou, Y. & Pitchumoni, C. S. Obesity, obesities and gastrointestinal cancers. Disease-a-Month 69(12), 101592 (2023).

    Article 
    PubMed 

    Google Scholar 

  • Genkinger, J. M., Kitahara, C. M., Bernstein, L., Berrington de Gonzalez, A., Brotzman, M., Elena, J. W. et al. Central adiposity, obesity during early adulthood, and pancreatic cancer mortality in a pooled analysis of cohort studies. Ann. Oncol. 26(11), 2257–2266 (2015).

  • Liu, X. et al. Overweight and obesity as independent factors for increased risk of hepatocellular cancer-related mortality: a meta-analysis. J. Am. Coll. Nutr. 40(3), 287–293 (2021).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Kim, H. S. et al. Synergistic associations of PNPLA3 I148M variant, alcohol intake, and obesity with risk of cirrhosis, hepatocellular carcinoma, and mortality. JAMA Netw. Open 5(10), e2234221 (2022).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Simon, T. G. et al. Physical activity compared to adiposity and risk of liver-related mortality: Results from two prospective, nationwide cohorts. J. Hepatol. 72(6), 1062–1069 (2020).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Emerenziani, S., Guarino, M. P. L., Trillo Asensio, L. M., Altomare, A., Ribolsi, M., Balestrieri, P. et al. Role of overweight and obesity in gastrointestinal disease. Nutrients 12(1) (2019).

  • Ze, E. Y., Kim, B. J., Kang, H. & Kim, J. G. Abdominal visceral to subcutaneous adipose tissue ratio is associated with increased risk of erosive esophagitis. Dig. Dis. Sci. 62(5), 1265–1271 (2017).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Lauby-Secretan, B. et al. Body fatness and cancer-viewpoint of the IARC Working Group. N. Engl. J. Med. 375(8), 794–798 (2016).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Kredel, L., Batra, A. & Siegmund, B. Role of fat and adipokines in intestinal inflammation. Curr. Opin. Gastroenterol. 30(6), 559–565 (2014).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Iacobini, C., Pugliese, G., Blasetti Fantauzzi, C., Federici, M. & Menini, S. Metabolically healthy versus metabolically unhealthy obesity. Metabolism 92, 51–60 (2019).

  • Lotta, L. A. et al. Integrative genomic analysis implicates limited peripheral adipose storage capacity in the pathogenesis of human insulin resistance. Nat. Genet. 49(1), 17–26 (2017).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Stefan, N., Schick, F. & Häring, H. U. Causes, characteristics, and consequences of metabolically unhealthy normal weight in humans. Cell Metab. 26(2), 292–300 (2017).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Michalsen, V. L. et al. Obesity measures, metabolic health and their association with 15-year all-cause and cardiovascular mortality in the SAMINOR 1 Survey: a population-based cohort study. BMC Cardiovasc. Disord. 21(1), 510 (2021).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Neeland, I. J. et al. Visceral and ectopic fat, atherosclerosis, and cardiometabolic disease: a position statement. Lancet Diabetes Endocrinol. 7(9), 715–725 (2019).

    Article 
    PubMed 

    Google Scholar 

  • Darin-Mattsson, A., Fors, S. & Kåreholt, I. Different indicators of socioeconomic status and their relative importance as determinants of health in old age. Int. J. Equity Health 16(1), 173 (2017).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Mackenbach, J. P. et al. Changes in mortality inequalities over two decades: register based study of European countries. BMJ (Clin. Res. Ed) 353, i1732 (2016).

    Google Scholar 

  • Chetty, R. et al. The association between income and life expectancy in the United States, 2001–2014. JAMA 315(16), 1750–1766 (2016).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Stringhini, S. et al. Socioeconomic status and the 25 × 25 risk factors as determinants of premature mortality: a multicohort study and meta-analysis of 1·7 million men and women. Lancet (London, England) 389(10075), 1229–1237 (2017).

    Article 
    PubMed 

    Google Scholar 

  • Kaul, S. et al. Modifiable health-related factors (smoking, physical activity and body mass index) and health care use and costs among adult cancer survivors. J. Cancer Res. Clin. Oncol. 143(12), 2469–2480 (2017).

    Article 
    PubMed 

    Google Scholar 

  • Schweda, S., Munz, B., Burgstahler, C., Niess, A. M., Roesel, I., Sudeck, G. et al. Proof of concept of a 6-month person-oriented exercise intervention ‘multipill-exercise’ among patients at risk of or with multiple chronic diseases: Results of a One-Group Pilot Trial. Int. J. Environ. Res. Public Health 19(15) (2022).

  • Wang, C., Zhang, X., Li, B. & Mu, D. A study of factors impacting disease based on the Charlson Comorbidity Index in UK Biobank. Front. Public Health 10, 1050129 (2022).

    Article 
    PubMed 

    Google Scholar 

  • Gardner, J. D. & Mouton, A. J. Alcohol effects on cardiac function. Compr. Physiol. 5(2), 791–802 (2015).

    Article 
    PubMed 

    Google Scholar 

  • Stockwell, T. et al. Do, “moderate” drinkers have reduced mortality risk? A systematic review and meta-analysis of alcohol consumption and all-cause mortality. J. Stud. Alcohol Drugs 77(2), 185–198 (2016).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Fekjaer, H. O. Alcohol-a universal preventive agent? A critical analysis. Addiction (Abingdon, England) 108(12), 2051–2057 (2013).

    Article 
    PubMed 

    Google Scholar 

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